Silencing the Siren

Silencing the Siren Guidance Cue Hierarchies at the CNS Midline

It is no coincidence that the CNS midline serves as one of the best studied axon guidance choice points since it is possible to observe here phylogenetically conserved neuronal guidance events that showcase many complex growth cone steering behaviors (Figure 1A). Ipsilaterally projecting axons that do not cross the midline, and con-tralaterally projecting axons that do have both been Our unders...

The Siren Organ

Sirens evoke images of alarm, public service, war, and forthcoming air raid. Outside of the music of Edgard Varése ([8], [9]), sirens have rarely been framed as musical instruments. By connecting air hoses to spinning disks with evenly-spaced perforations, the siren timbre is translated musically. Polyphony gives our instrument an organ-like personality: keys are mapped to different frequencies...

Siren Song of Segmentation

SIREN - A Network Infrastructure for Emergencies

In emergencies or disasters a key support factor for situation awareness, decision making and response is to provide a secure and dependable network infrastructure that aggregates connectivity over all available heterogeneous wireless broadband access technologies, including those employed for commercial network access. The infrastructure must be able to adapt to mission critical application re...

The siren song of simple tools that predict mortality.

Hippocrates recognized that determining a patient’s prognosis is one of physicians’ most important responsibilities.1 Although research on prognosis has been outpaced by that on etiology and therapy, scientists have made great strides in characterizing the risk factors for death across all areas of medicine.2 However, this deeper understanding of prognosis comes at the expense of simplicity; in...